Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

Heparin is required for the binding of basic fibroblast growth factor (bFGF) to high-affinity receptors on cells deficient in cell surface heparan sulfate proteoglycan. So that this heparin requirement could be evaluated in the absence of other cell surface molecules, we designed a simple assay base...

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Auteurs principaux: Ornitz, D M, Yayon, A, Flanagan, J G, Svahn, C M, Levi, E, Leder, P
Format: Artigo
Langue:Inglês
Publié: 1992
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC364088/
https://ncbi.nlm.nih.gov/pubmed/1309590
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