A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C.

Cells expressing mutant epidermal growth factor (EGF) receptors have been used to study mechanisms through which EGF increases phospholipase C (PLC) activity. C-terminal truncation mutant EGF receptors are markedly impaired in their ability to increase inositol phosphate formation compared with wild...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Vega, Q C, Cochet, C, Filhol, O, Chang, C P, Rhee, S G, Gill, G N
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1992
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364076/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1729595/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.1.128-135.1992
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