A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C.

Cells expressing mutant epidermal growth factor (EGF) receptors have been used to study mechanisms through which EGF increases phospholipase C (PLC) activity. C-terminal truncation mutant EGF receptors are markedly impaired in their ability to increase inositol phosphate formation compared with wild...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	Vega, Q C, Cochet, C, Filhol, O, Chang, C P, Rhee, S G, Gill, G N
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 1992
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364076/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1729595/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.1.128-135.1992
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