A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C.

Cells expressing mutant epidermal growth factor (EGF) receptors have been used to study mechanisms through which EGF increases phospholipase C (PLC) activity. C-terminal truncation mutant EGF receptors are markedly impaired in their ability to increase inositol phosphate formation compared with wild...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Vega, Q C, Cochet, C, Filhol, O, Chang, C P, Rhee, S G, Gill, G N
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364076/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1729595/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.1.128
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