Inhibition of TGF-β Enhances the In Vivo Antitumor Efficacy of EGF Receptor–Targeted Therapy

EGF receptor (EGFR)–targeted monoclonal antibodies (mAb), such as cetuximab, execute their antitumor effect in vivo via blockade of receptor–ligand interactions and engagement of Fcγ receptors on immune effector cells that trigger antibody-dependent cell-mediated cytotoxicity (ADCC). We show that tu...

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Bibliografiska uppgifter
Huvudupphovsmän: Bedi, Atul, Chang, Xiaofei, Noonan, Kimberly, Pham, Vui, Bedi, Rishi, Fertig, Elana J., Considine, Michael, Califano, Joseph A., Borrello, Ivan, Chung, Christine H., Sidransky, David, Ravi, Rajani
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640459/
https://ncbi.nlm.nih.gov/pubmed/22927667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0101-T
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