Inhibition of TGF-β Enhances the In Vivo Antitumor Efficacy of EGF Receptor–Targeted Therapy

EGF receptor (EGFR)–targeted monoclonal antibodies (mAb), such as cetuximab, execute their antitumor effect in vivo via blockade of receptor–ligand interactions and engagement of Fcγ receptors on immune effector cells that trigger antibody-dependent cell-mediated cytotoxicity (ADCC). We show that tu...

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Detalhes bibliográficos
Main Authors: Bedi, Atul, Chang, Xiaofei, Noonan, Kimberly, Pham, Vui, Bedi, Rishi, Fertig, Elana J., Considine, Michael, Califano, Joseph A., Borrello, Ivan, Chung, Christine H., Sidransky, David, Ravi, Rajani
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640459/
https://ncbi.nlm.nih.gov/pubmed/22927667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0101-T
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