Inhibition of TGF-β Enhances the In Vivo Antitumor Efficacy of EGF Receptor–Targeted Therapy

EGF receptor (EGFR)–targeted monoclonal antibodies (mAb), such as cetuximab, execute their antitumor effect in vivo via blockade of receptor–ligand interactions and engagement of Fcγ receptors on immune effector cells that trigger antibody-dependent cell-mediated cytotoxicity (ADCC). We show that tu...

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Main Authors: Bedi, Atul, Chang, Xiaofei, Noonan, Kimberly, Pham, Vui, Bedi, Rishi, Fertig, Elana J., Considine, Michael, Califano, Joseph A., Borrello, Ivan, Chung, Christine H., Sidransky, David, Ravi, Rajani
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640459/
https://ncbi.nlm.nih.gov/pubmed/22927667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0101-T
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