Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

Phosphodiesterase-5 (PDE5) inhibitors (sildenafil, tadalafil, and vardenafil) are agents currently in clinical use for nonmalignant conditions. We report the use of PDE5 inhibitors as modulators of the antitumor immune response. In several mouse tumor models, PDE5 inhibition reverses tumor-induced i...

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Xehetasun bibliografikoak
Egile Nagusiak: Serafini, Paolo, Meckel, Kristen, Kelso, Michael, Noonan, Kimberly, Califano, Joseph, Koch, Wayne, Dolcetti, Luigi, Bronte, Vincenzo, Borrello, Ivan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2006
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118163/
https://ncbi.nlm.nih.gov/pubmed/17101732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061104
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