The TGFβ-miR200-Mig6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors

While specific mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) identify tumors that are responsive to EGFR tyrosine kinase inhibitors (TKIs), these genetic alterations are present in only a minority of patients. Patients with tumors expressing wild-type (wt) EGFR l...

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Detalhes bibliográficos
Main Authors: Izumchenko, Evgeny, Chang, Xiaofei, Michailidi, Christina, Kagohara, Luciane, Ravi, Rajani, Paz, Keren, Brait, Mariana, Hoque, Mohammad, Ling, Shizhang, Bedi, Atul, Sidransky, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122100/
https://ncbi.nlm.nih.gov/pubmed/24830724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0110
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