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α-Synuclein Can Inhibit SNARE-mediated Vesicle Fusion Through Direct Interactions with Lipid Bilayers

The native function of α-synuclein is thought to involve regulation of synaptic vesicle trafficking. Recent work has also implicated a role in neurotransmission, possibly through interactions with the proteins involved in synaptic vesicle fusion. Here, we demonstrate that α-synuclein inhibits SNARE-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DeWitt, David C., Rhoades, Elizabeth
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640401/
https://ncbi.nlm.nih.gov/pubmed/23528131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4002369
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