Pharmacokinetics and Metabolism of 2-Aminothiazoles with Antiprion Activity in Mice

PURPOSE: To discover drugs lowering PrP(Sc) in prion-infected cultured neuronal cells that achieve high concentrations in brain to test in mouse models of prion disease and then treat people with these fatal diseases. METHODS: We tested 2-AMT analogs for EC(50) and PK after a 40 mg/kg single dose an...

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Main Authors: Silber, B. Michael, Rao, Satish, Fife, Kimberly L., Gallardo-Godoy, Alejandra, Renslo, Adam R., Dalvie, Deepak K., Giles, Kurt, Freyman, Yevgeniy, Elepano, Manuel, Gever, Joel R., Li, Zhe, Jacobson, Matthew P., Huang, Yong, Benet, Leslie Z., Prusiner, Stanley B.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640342/
https://ncbi.nlm.nih.gov/pubmed/23417511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-012-0912-4
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