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Blocking HIV-1 entry by a gp120 surface binding inhibitor
We report the mode of action of a proteomimetic compound that binds to the exterior surface of gp120 and blocks HIV-1 entry into cells. Using a one cycle time-of-addition study and antibody competition binding studies, we have determined that the compound blocks HIV-1 entry through modulation of key...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3640310/ https://ncbi.nlm.nih.gov/pubmed/22487177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.02.079 |
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