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Human RNA methyltransferase BCDIN3D regulates microRNA processing

MicroRNAs regulate key biological processes and their aberrant expression may lead to cancer. The primary transcript of canonical miRNAs is sequentially cleaved by the RNase III enzymes, Drosha and Dicer, which generate 5′mono-phosphate ends that are important for subsequent miRNA functions. In part...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Xhemalce, Blerta, Robson, Samuel C, Kouzarides, Tony
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640255/
https://ncbi.nlm.nih.gov/pubmed/23063121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.08.041
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