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Human RNA methyltransferase BCDIN3D regulates microRNA processing

MicroRNAs regulate key biological processes and their aberrant expression may lead to cancer. The primary transcript of canonical miRNAs is sequentially cleaved by the RNase III enzymes, Drosha and Dicer, which generate 5′mono-phosphate ends that are important for subsequent miRNA functions. In part...

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Hlavní autoři: Xhemalce, Blerta, Robson, Samuel C, Kouzarides, Tony
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640255/
https://ncbi.nlm.nih.gov/pubmed/23063121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.08.041
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