Inhibition of p38MAPK and CD137 signaling reduce dengue virus-induced TNF-α secretion and apoptosis

BACKGROUND: Hepatic injury in dengue virus (DENV) infection is authenticated by hepatomegaly and an upsurge in transaminase levels. DENV replicates in hepatocytes and causes hepatocyte apoptosis both in vitro and in vivo. Understanding the molecular mechanisms of DENV-induced hepatic injury could fa...

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Dettagli Bibliografici
Autori principali: Nagila, Amar, Netsawang, Janjuree, Suttitheptumrong, Aroonroong, Morchang, Atthapan, Khunchai, Sasiprapa, Srisawat, Chatchawan, Puttikhunt, Chunya, Noisakran, Sansanee, Yenchitsomanus, Pa-thai, Limjindaporn, Thawornchai
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Short Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639879/
https://ncbi.nlm.nih.gov/pubmed/23557259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-10-105
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