Inhibition of p38MAPK and CD137 signaling reduce dengue virus-induced TNF-α secretion and apoptosis

BACKGROUND: Hepatic injury in dengue virus (DENV) infection is authenticated by hepatomegaly and an upsurge in transaminase levels. DENV replicates in hepatocytes and causes hepatocyte apoptosis both in vitro and in vivo. Understanding the molecular mechanisms of DENV-induced hepatic injury could fa...

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Главные авторы: Nagila, Amar, Netsawang, Janjuree, Suttitheptumrong, Aroonroong, Morchang, Atthapan, Khunchai, Sasiprapa, Srisawat, Chatchawan, Puttikhunt, Chunya, Noisakran, Sansanee, Yenchitsomanus, Pa-thai, Limjindaporn, Thawornchai
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2013
Предметы:
Short Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639879/
https://ncbi.nlm.nih.gov/pubmed/23557259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-10-105
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