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From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design
[Image: see text] Comparative analyses of the pharmacophoric elements required for σ1 and nicotinic ligands led to the identification of a potent and selective σ1 ligand (15). Compound 15 displayed high selectivity for the σ1 receptor (K(i), σ1 = 4.1 nM; K(i), σ2 = 1312 nM) with moderate binding aff...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3638970/ https://ncbi.nlm.nih.gov/pubmed/23641311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3002715 |
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