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Preparation and application of a “clickable” acceptor for enzymatic synthesis of heparin oligosaccharides

A “clickable” disaccharide was prepared by treating the aldehyde precursor with hydroxylamine, followed by the catalytic hydrogenation and diazotransfer reaction. This disaccharide was successfully applied to the elongation of the backbone construction of ultralow molecular weight (ULMW) heparins us...

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Main Authors: Cai, Chao, Edgar, Kristi, Liu, Jian, Linhardt, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638765/
https://ncbi.nlm.nih.gov/pubmed/23524108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carres.2013.02.010
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