Targeted Therapy for BRAF(V600E) Malignant Astrocytoma

PURPOSE: Malignant astrocytomas (MAs) are aggressive central nervous system tumors with poor prognosis. Activating mutation of BRAF (BRAF(V600E)) has been reported in a subset of these tumors, especially in children. We have investigated the incidence of BRAF(V600E) in additional pediatric patient c...

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Auteurs principaux: Nicolaides, Theodore P., Li, Huifang, Solomon, David A., Hariono, Sujatmi, Hashizume, Rintaro, Barkovich, Krister, Baker, Suzanne J., Paugh, Barbara S., Jones, Chris, Forshew, Tim, Hindley, Guy F., Hodgson, J. Graeme, Kim, Jung-Sik, Rowitch, David H., Weiss, William A., Waldman, Todd A., James, C. David
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638050/
https://ncbi.nlm.nih.gov/pubmed/22038996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1456
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