Cooperative interactions of BRAF(V600E) kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy

Although malignant astrocytomas are a leading cause of cancer-related death in children, rational therapeutic strategies are lacking. We previously identified activating mutations of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) (BRAF(T1799A) encoding BRAF(V600E)) in association with homozyg...

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Detalhes bibliográficos
Main Authors: Huillard, Emmanuelle, Hashizume, Rintaro, Phillips, Joanna J., Griveau, Amélie, Ihrie, Rebecca A., Aoki, Yasuyuki, Nicolaides, Theodore, Perry, Arie, Waldman, Todd, McMahon, Martin, Weiss, William A., Petritsch, Claudia, James, C. David, Rowitch, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365162/
https://ncbi.nlm.nih.gov/pubmed/22586120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117255109
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