Targeting Photoreceptors via Intravitreal Delivery Using Novel, Capsid-Mutated AAV Vectors

Development of viral vectors capable of transducing photoreceptors by less invasive methods than subretinal injection would provide a major advancement in retinal gene therapy. We sought to develop novel AAV vectors optimized for photoreceptor transduction following intravitreal delivery and to deve...

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Détails bibliographiques
Auteurs principaux: Kay, Christine N., Ryals, Renee C., Aslanidi, George V., Min, Seok Hong, Ruan, Qing, Sun, Jingfen, Dyka, Frank M., Kasuga, Daniel, Ayala, Andrea E., Van Vliet, Kim, Agbandje-McKenna, Mavis, Hauswirth, William W., Boye, Sanford L., Boye, Shannon E.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637363/
https://ncbi.nlm.nih.gov/pubmed/23637972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062097
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