AKAP13 Rho-GEF and PKD-Binding Domain Deficient Mice Develop Normally but Have an Abnormal Response to β-Adrenergic-Induced Cardiac Hypertrophy

BACKGROUND: A-kinase anchoring proteins (AKAPs) are scaffolding molecules that coordinate and integrate G-protein signaling events to regulate development, physiology, and disease. One family member, AKAP13, encodes for multiple protein isoforms that contain binding sites for protein kinase A (PKA)...

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Main Authors: Spindler, Matthew J., Burmeister, Brian T., Huang, Yu, Hsiao, Edward C., Salomonis, Nathan, Scott, Mark J., Srivastava, Deepak, Carnegie, Graeme K., Conklin, Bruce R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637253/
https://ncbi.nlm.nih.gov/pubmed/23658642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062705
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