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Molecular Insights into the Reversible Formation of Tau Protein Fibrils
We computationally and experimentally showed that tau protein fibrils can be formed at high temperature. When cooled, the fibrils dissociate back to monomers. Heparin promotes tau fibril formation and prevents its reversion. Our results revealed the physicochemical mechanism of reversible formation...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3637047/ https://ncbi.nlm.nih.gov/pubmed/23527380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc00241a |
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