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Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells
An understanding of the human fetal to adult hemoglobin switch offers the potential to ameliorate β-type globin gene disorders such as sickle cell anemia and β-thalassemia through activation of the fetal γ-globin gene. Chromatin modifying complexes, including MBD2-NuRD and GATA-1/FOG-1/NuRD, play a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3637018/ https://ncbi.nlm.nih.gov/pubmed/23444401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-11-466227 |
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