An efferocytosis-induced, IL-4–dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD

Efferocytosis of apoptotic neutrophils by macrophages following tissue injury is fundamental to the resolution of inflammation and initiation of tissue repair. Using a sterile peritonitis model in mice, we identified interleukin (IL)-4–producing efferocytosing macrophages in the peritoneum that acti...

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Main Authors: Zeng, Melody Yue, Pham, Duy, Bagaitkar, Juhi, Liu, Jianyun, Otero, Karel, Shan, Ming, Wynn, Thomas A., Brombacher, Frank, Brutkiewicz, Randy R., Kaplan, Mark H., Dinauer, Mary C.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2013
Teme:
Phagocytes, Granulocytes, and Myelopoiesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637016/
https://ncbi.nlm.nih.gov/pubmed/23426944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-10-461913
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