Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes

The normal β-cell response to obesity-associated insulin resistance is hypersecretion of insulin. Type 2 diabetes develops in subjects with β-cells that are susceptible to failure. Here, we investigated the time-dependent gene expression changes in islets of diabetes-prone db/db and diabetes-resista...

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Bibliographic Details
Main Authors: Chan, Jeng Yie, Luzuriaga, Jude, Bensellam, Mohammed, Biden, Trevor J., Laybutt, D. Ross
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2013
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636637/
https://ncbi.nlm.nih.gov/pubmed/23274897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0701
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