Effect of Alanine Replacement of L17 and F19 on the Aggregation and Neurotoxicity of Arctic-Type Aβ(40)

Alzheimer’s disease is the most common form of neurodegenerative disease. Beta-amyloid peptides (Aβ) are responsible for neuronal death both in vitro and in vivo. Previously, L17 and F19 residues were identified as playing key roles in the stabilization of the Aβ(40) conformation and in the reductio...

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Main Authors: Chen, Yi-Ru, Huang, Hsien-bin, Lo, Chi-Jen, Wang, Chih-Ching, Ho, Li-Kang, Liu, Hsin-Tzu, Shiao, Ming-Shi, Lin, Ta-Hsien, Chen, Yi-Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636269/
https://ncbi.nlm.nih.gov/pubmed/23634215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061874
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