L17A/F19A Substitutions Augment the α-Helicity of β-Amyloid Peptide Discordant Segment

β-amyloid peptide (Aβ) aggregation has been thought to be associated with the pathogenesis of Alzheimer’s disease. Recently, we showed that L17A/F19A substitutions may increase the structural stability of wild-type and Arctic-type Aβ(40) and decrease the rates of structural conversion and fibril for...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Liang, Chu-Ting, Huang, Hsien-Bin, Wang, Chih-Ching, Chen, Yi-Ru, Chang, Chi-Fon, Shiao, Ming-Shi, Chen, Yi-Cheng, Lin, Ta-Hsien
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841593/
https://ncbi.nlm.nih.gov/pubmed/27104649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154327
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