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T cell anergy, exhaustion, senescence and stemness in the tumor microenvironment
Human tumors progress despite the presence of tumor associated antigen (TAA)-specific T cells. Many different molecular and cellular mechanisms contribute to the failure of T cells to eradicate the tumor. These include immune suppressive networks that impair ongoing T cell function and enable tumor...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3636159/ https://ncbi.nlm.nih.gov/pubmed/23298609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2012.12.003 |
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