Human Germline Antibody Gene Segments Encode Polyspecific Antibodies

Structural flexibility in germline gene-encoded antibodies allows promiscuous binding to diverse antigens. The binding affinity and specificity for a particular epitope typically increase as antibody genes acquire somatic mutations in antigen-stimulated B cells. In this work, we investigated whether...

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Hauptverfasser: Willis, Jordan R., Briney, Bryan S., DeLuca, Samuel L., Crowe, James E., Meiler, Jens
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636087/
https://ncbi.nlm.nih.gov/pubmed/23637590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003045
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