Mutations in the RB1 gene and their effects on transcription.

Inactivation of both alleles of the RB1 gene during normal retinal development initiates the formation of a retinoblastoma (RB) tumor. To identify the mutations which inactivate RB1, 21 RB tumors isolated from 19 patients were analyzed with the polymerase chain reaction or an RNase protection assay...

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Bibliographic Details
Main Authors: Dunn, J M, Phillips, R A, Zhu, X, Becker, A, Gallie, B L
Format: Artigo
Language:Inglês
Published: 1989
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC363605/
https://ncbi.nlm.nih.gov/pubmed/2601691
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