Mutations in the RB1 gene and their effects on transcription.

Inactivation of both alleles of the RB1 gene during normal retinal development initiates the formation of a retinoblastoma (RB) tumor. To identify the mutations which inactivate RB1, 21 RB tumors isolated from 19 patients were analyzed with the polymerase chain reaction or an RNase protection assay...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Dunn, J M, Phillips, R A, Zhu, X, Becker, A, Gallie, B L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363605/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2601691/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.11.4596-4604.1989
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