Transcriptional Repression by Rb-E2F and Regulation of Anchorage-Independent Survival

Mutations that lead to anchorage-independent survival are a hallmark of tumor cells. Adhesion of integrin receptors to extracellular matrix activates a survival signaling pathway in epithelial cells where Akt phosphorylates and blocks the activity of proapoptotic proteins such as the BCL2 family mem...

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Main Authors: Yu, Jennifer T., Foster, Rosalinda G., Dean, Douglas C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Transcriptional Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC100254/
https://ncbi.nlm.nih.gov/pubmed/11313458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.10.3325-3335.2001
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