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Transcriptional Repression by Rb-E2F and Regulation of Anchorage-Independent Survival
Mutations that lead to anchorage-independent survival are a hallmark of tumor cells. Adhesion of integrin receptors to extracellular matrix activates a survival signaling pathway in epithelial cells where Akt phosphorylates and blocks the activity of proapoptotic proteins such as the BCL2 family mem...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2001
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC100254/ https://ncbi.nlm.nih.gov/pubmed/11313458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.10.3325-3335.2001 |
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