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Transcriptional Repression by Rb-E2F and Regulation of Anchorage-Independent Survival
Mutations that lead to anchorage-independent survival are a hallmark of tumor cells. Adhesion of integrin receptors to extracellular matrix activates a survival signaling pathway in epithelial cells where Akt phosphorylates and blocks the activity of proapoptotic proteins such as the BCL2 family mem...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC100254/ https://ncbi.nlm.nih.gov/pubmed/11313458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.10.3325-3335.2001 |
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