Transcriptional Repression by Rb-E2F and Regulation of Anchorage-Independent Survival
Mutations that lead to anchorage-independent survival are a hallmark of tumor cells. Adhesion of integrin receptors to extracellular matrix activates a survival signaling pathway in epithelial cells where Akt phosphorylates and blocks the activity of proapoptotic proteins such as the BCL2 family mem...
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| Veröffentlicht in: | Mol Cell Biol |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2001
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC100254/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11313458/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.10.3325-3335.2001 |
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