PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance

Diabetes is a metabolic disorder characterized by hyperglycemia. Insulin, which is secreted by pancreatic beta cells, is recognized as the critical regulator of blood glucose, but the molecular machinery responsible for insulin trafficking remains poorly defined. In particular, the roles of cytosoli...

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Autori principali: Cao, Mian, Mao, Zhuo, Kam, Chuen, Xiao, Nan, Cao, Xiaoxing, Shen, Chong, Cheng, Kenneth K. Y., Xu, Aimin, Lee, Kwong-Man, Jiang, Liwen, Xia, Jun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635858/
https://ncbi.nlm.nih.gov/pubmed/23630453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001541
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