PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance

Diabetes is a metabolic disorder characterized by hyperglycemia. Insulin, which is secreted by pancreatic beta cells, is recognized as the critical regulator of blood glucose, but the molecular machinery responsible for insulin trafficking remains poorly defined. In particular, the roles of cytosoli...

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Detalhes bibliográficos
Main Authors: Cao, Mian, Mao, Zhuo, Kam, Chuen, Xiao, Nan, Cao, Xiaoxing, Shen, Chong, Cheng, Kenneth K. Y., Xu, Aimin, Lee, Kwong-Man, Jiang, Liwen, Xia, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635858/
https://ncbi.nlm.nih.gov/pubmed/23630453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001541
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