Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs

Critically short telomeres activate p53-mediated apoptosis, resulting in organ failure and leading to malignant transformation. Mutations in genes responsible for telomere maintenance are linked to a number of human diseases. We derived induced pluripotent stem cells (iPSCs) from 4 patients with apl...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Winkler, Thomas, Hong, So Gun, Decker, Jake E., Morgan, Mary J., Wu, Chuanfeng, Hughes, William M., Yang, Yanqin, Wangsa, Danny, Padilla-Nash, Hesed M., Ried, Thomas, Young, Neal S., Dunbar, Cynthia E., Calado, Rodrigo T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2013
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635755/
https://ncbi.nlm.nih.gov/pubmed/23585473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67146
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak