Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs

Critically short telomeres activate p53-mediated apoptosis, resulting in organ failure and leading to malignant transformation. Mutations in genes responsible for telomere maintenance are linked to a number of human diseases. We derived induced pluripotent stem cells (iPSCs) from 4 patients with apl...

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Detalhes bibliográficos
Main Authors: Winkler, Thomas, Hong, So Gun, Decker, Jake E., Morgan, Mary J., Wu, Chuanfeng, Hughes, William M., Yang, Yanqin, Wangsa, Danny, Padilla-Nash, Hesed M., Ried, Thomas, Young, Neal S., Dunbar, Cynthia E., Calado, Rodrigo T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635755/
https://ncbi.nlm.nih.gov/pubmed/23585473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67146
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