Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia

In cell and animal models, telomere erosion promotes chromosomal instability via breakage-fusion-bridge cycles, contributing to the early stages of tumorigenesis. However, evidence involving short telomeres in cancer development in humans is scarce, epidemiologic, and indirect. Here we directly impl...

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Bibliographic Details
Main Authors: Calado, Rodrigo T., Cooper, James N., Padilla-Nash, Hesed M., Sloand, Elaine M., Wu, Colin O., Scheinberg, Phillip, Ried, Thomas, Young, Neal S.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169071/
https://ncbi.nlm.nih.gov/pubmed/22005790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.272
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