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Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia
In cell and animal models, telomere erosion promotes chromosomal instability via breakage-fusion-bridge cycles, contributing to the early stages of tumorigenesis. However, evidence involving short telomeres in cancer development in humans is scarce, epidemiologic, and indirect. Here we directly impl...
Tallennettuna:
| Päätekijät: | , , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4169071/ https://ncbi.nlm.nih.gov/pubmed/22005790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.272 |
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