Discovery of ML326: the first sub-micromolar, selective M(5) PAM

This letter describes the further chemical optimization of the M(5) PAM MLPCN probes ML129 and ML172. A multi-dimensional iterative parallel synthesis effort quickly explored isatin replacements and a number of southern heterobiaryl variations with no improvement over ML129 and ML172. An HTS campaig...

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Main Authors: Gentry, Patirck R., Bridges, Thomas M., Lamasal, Atin, Vinson, Paige N., Smith, Emery, Chase, Peter, Hodder, Peter S., Engers, Julie L., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Wood, Michael R., Lindsley, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634896/
https://ncbi.nlm.nih.gov/pubmed/23562060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.03.032
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