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Optimum Design of Disease-modifying Trials on Alzheimer’s Disease
Randomized start and withdrawal designs have been recently proposed to test the disease-modifying agents on Alzheimer’s disease (AD). This article provides methods to determine the optimum parameters for these designs. A general linear mixed effects model is proposed. This model employs a piecewise...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3634601/ https://ncbi.nlm.nih.gov/pubmed/23626866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19466315.2011.634757 |
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