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Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe

BACKGROUND & AIMS: HFE and transferrin receptor 2 (TFR2) are each necessary for the normal relationship between body iron status and liver hepcidin expression. In murine Hfe and Tfr2 knockout models of hereditary hemochromatosis (HH), signal transduction to hepcidin via the bone morphogenetic pr...

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Bibliografiske detaljer
Main Authors: Corradini, Elena, Rozier, Molly, Meynard, Delphine, Odhiambo, Adam, Lin, Herbert Y., Feng, Qi, Migas, Mary C., Britton, Robert S., Babitt, Jodie L., Fleming, Robert E.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634343/
https://ncbi.nlm.nih.gov/pubmed/21745449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.06.077
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