Functional Genomic Analyses Identify Pathways Dysregulated by Progranulin Deficiency Implicating Wnt Signaling

Progranulin (GRN) mutations cause frontotemporal dementia (FTD), but GRN’s function in the CNS remains largely unknown. To identify the pathways downstream of GRN, we used weighted gene co-expression network analysis (WGCNA) to develop a systems-level view of transcriptional alterations in a human n...

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Detalhes bibliográficos
Main Authors: Rosen, Ezra Y., Wexler, Eric M., Versano, Revital, Coppola, Giovanni, Gao, Fuying, Winden, Kellen D., Oldham, Michael C., Martens, Lauren Herl, Zhou, Ping, Farese, Robert V., Geschwind, Daniel H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633414/
https://ncbi.nlm.nih.gov/pubmed/21943601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.07.021
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