TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

Replication of the mammalian mitochondrial DNA (mtDNA) is dependent on the minimal replisome, consisting of the heterotrimeric mtDNA polymerase (POLG), the hexameric DNA helicase TWINKLE and the tetrameric single-stranded DNA-binding protein (mtSSB). TWINKLE has been shown to unwind DNA during the r...

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Autores principales: Milenkovic, Dusanka, Matic, Stanka, Kühl, Inge, Ruzzenente, Benedetta, Freyer, Christoph, Jemt, Elisabeth, Park, Chan Bae, Falkenberg, Maria, Larsson, Nils-Göran
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2013
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633371/
https://ncbi.nlm.nih.gov/pubmed/23393161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt051
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