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The Molecular Basis of β-Thalassemia

The β-thalassemias are characterized by a quantitative deficiency of β-globin chains underlaid by a striking heterogeneity of molecular defects. Although most of the molecular lesions involve the structural β gene directly, some down-regulate the gene through distal cis effects, and rare trans-actin...

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Bibliografische gegevens
Hoofdauteur: Thein, Swee Lay
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633182/
https://ncbi.nlm.nih.gov/pubmed/23637309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a011700
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