Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2

AIMS: Although aberrant Ca(2+) release (i.e. Ca(2+) ‘leak’) from the sarcoplasmic reticulum (SR) through cardiac ryanodine receptors (RyR2) is linked to heart failure (HF), it remains unknown whether and under what conditions SR-derived Ca(2+) can actually cause HF. We tested the hypothesis that com...

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Main Authors: Kalyanasundaram, Anuradha, Lacombe, Véronique A., Belevych, Andriy E., Brunello, Lucia, Carnes, Cynthia A., Janssen, Paul M.L., Knollmann, Bjørn C., Periasamy, Muthu, Gyørke, Sandor
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Original Articles: Spotlight on T-Tubules and Ryanodine Receptor Microdomain Signalling in Cardiac Hypertrophy and Failure
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633154/
https://ncbi.nlm.nih.gov/pubmed/23135969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs334
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