A structural and molecular dynamics approach to understanding the peptide-receptive transition state of MHC-I molecules()

The mature conformation of major histocompatibility complex class I (MHC-I) proteins depends on the presence of bound peptides, permitting recognition at the cell surface by CD8(+) T lymphocytes. Newly synthesized MHC-I molecules in the endoplasmic reticulum are maintained in a peptide-receptive (PR...

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Detalhes bibliográficos
Main Authors: Mage, Michael G., Dolan, Michael A., Wang, Rui, Boyd, Lisa F., Revilleza, Maria Jamela, Robinson, Howard, Natarajan, Kannan, Myers, Nancy B., Hansen, Ted H., Margulies, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632263/
https://ncbi.nlm.nih.gov/pubmed/23200143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2012.10.021
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