THE PEPTIDE-RECEPTIVE TRANSITION STATE OF MHC-I MOLECULES: INSIGHT FROM STRUCTURE AND MOLECULAR DYNAMICS

MHC-I proteins of the adaptive immune system require antigenic peptides for maintenance of mature conformation and immune function via specific recognition by MHC-I-restricted CD8(+) T lymphocytes. New MHC-I molecules in the endoplasmic reticulum are held by chaperones in a peptide-receptive (PR) tr...

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Detalhes bibliográficos
Main Authors: Mage, Michael G., Dolan, Michael A., Wang, Rui, Boyd, Lisa F., Revilleza, Maria Jamela, Robinson, Howard, Natarajan, Kannan, Myers, Nancy B., Hansen, Ted H., Margulies, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422668/
https://ncbi.nlm.nih.gov/pubmed/22753930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200831
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