A far-upstream (−70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration

SOX9 encodes a transcription factor that presides over the specification and differentiation of numerous progenitor and differentiated cell types, and although SOX9 haploinsufficiency and overexpression cause severe diseases in humans, including campomelic dysplasia, sex reversal and cancer, the mec...

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Autori principali: Mead, Timothy J., Wang, Qiuqing, Bhattaram, Pallavi, Dy, Peter, Afelik, Solomon, Jensen, Jan, Lefebvre, Véronique
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
Soggetti:
Gene Regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632127/
https://ncbi.nlm.nih.gov/pubmed/23449223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt140
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