Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

The regulation and coordination of mitochondrial metabolism with hematopoietic stem cell (HSC) self-renewal and differentiation is not fully understood. Here we report that depletion of PTPMT1, a PTEN-like mitochondrial phosphatase, in inducible or hematopoietic-cell-specific knockout mice resulted...

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Hlavní autoři: Yu, Wen-Mei, Liu, Xia, Shen, Jinhua, Jovanovic, Olga, Pohl, Elena E., Gerson, Stanton L., Finkel, Toren, Broxmeyer, Hal E., Qu, Cheng-Kui
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632072/
https://ncbi.nlm.nih.gov/pubmed/23290137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.11.022
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