Probing DNA shape and methylation state on a genomic scale with DNase I

DNA binding proteins find their cognate sequences within genomic DNA through recognition of specific chemical and structural features. Here we demonstrate that high-resolution DNase I cleavage profiles can provide detailed information about the shape and chemical modification status of genomic DNA....

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Main Authors: Lazarovici, Allan, Zhou, Tianyin, Shafer, Anthony, Dantas Machado, Ana Carolina, Riley, Todd R., Sandstrom, Richard, Sabo, Peter J., Lu, Yan, Rohs, Remo, Stamatoyannopoulos, John A., Bussemaker, Harmen J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631675/
https://ncbi.nlm.nih.gov/pubmed/23576721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216822110
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