Synthetic microRNA-mediated downregulation of Nogo-A in transgenic rats reveals its role as regulator of synaptic plasticity and cognitive function

We have generated a transgenic rat model using RNAi and used it to study the role of the membrane protein Nogo-A in synaptic plasticity and cognition. The membrane protein Nogo-A is expressed in CNS oligodendrocytes and subpopulations of neurons, and it is known to suppress neurite growth and regene...

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Bibliografische gegevens
Hoofdauteurs: Tews, Björn, Schönig, Kai, Arzt, Michael E., Clementi, Stefano, Rioult-Pedotti, Mengia-Seraina, Zemmar, Ajmal, Berger, Stefan M., Schneider, Miriam, Enkel, Thomas, Weinmann, Oliver, Kasper, Hansjörg, Schwab, Martin E., Bartsch, Dusan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2013
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631667/
https://ncbi.nlm.nih.gov/pubmed/23576723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217665110
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