Mining the antibodyome for HIV-1–neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

Next-generation sequencing of antibody transcripts from HIV-1–infected individuals with broadly neutralizing antibodies could provide an efficient means for identifying somatic variants and characterizing their lineages. Here, we used 454 pyrosequencing and identity/divergence grid sampling to analy...

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Hauptverfasser: Zhu, Jiang, Ofek, Gilad, Yang, Yongping, Zhang, Baoshan, Louder, Mark K., Lu, Gabriel, McKee, Krisha, Pancera, Marie, Skinner, Jeff, Zhang, Zhenhai, Parks, Robert, Eudailey, Joshua, Lloyd, Krissey E., Blinn, Julie, Alam, S. Munir, Haynes, Barton F., Simek, Melissa, Burton, Dennis R., Koff, Wayne C., Mullikin, James C., Mascola, John R., Shapiro, Lawrence, Kwong, Peter D., Becker, Jesse, Benjamin, Betty, Blakesley, Robert, Bouffard, Gerry, Brooks, Shelise, Coleman, Holly, Dekhtyar, Mila, Gregory, Michael, Guan, Xiaobin, Gupta, Jyoti, Han, Joel, Hargrove, April, Ho, Shi-ling, Johnson, Taccara, Legaspi, Richelle, Lovett, Sean, Maduro, Quino, Masiello, Cathy, Maskeri, Baishali, McDowell, Jenny, Montemayor, Casandra, Mullikin, James, Park, Morgan, Riebow, Nancy, Schandler, Karen, Schmidt, Brian, Sison, Christina, Stantripop, Mal, Thomas, James, Thomas, Pam, Vemulapalli, Meg, Young, Alice
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631616/
https://ncbi.nlm.nih.gov/pubmed/23536288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219320110
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